1665. As the plague runs rife through London, Reverend William Mompesson arrives in Eyam, Derbyshire, to lead the parish. But Eyam is no sleepy backwater; it is a village at war with itself. The community has dissolved, and neighbour feuds with neighbour under the watchful eye of a ruthless landowner bent on maintaining his grip on the village. When the plague arrives in Eyam, the villagers are tasked with examining their civil responsibility, as they must decide whether to stay quarantined, or flee and risk spreading the deadly disease.